Cambio - Excellence in Molecular Biology

In Vitro Toxicology

In Vitro Toxicology: Mutagenicity kits

The Ames II / Ames MPF Microfluctuation Assays are all modifications of the traditional Ames plate incorporation assay. The Ames II assay uses the S. typhimurium strains TA98 and TAMix (a mixture of 6 strains, each detecting a specific base-pair substitution), whereas the Ames MPF® kits are available with the strains TA98, TA100, TA1535, TA1537, E.coli WP2 uvrA or E.coli WP2 pKM101.

Benefits of Xenometrix Ames Mutagenicity Assays over traditional Ames Procedures

  • Easy, compact and high throughput liquid format with 384 well plates.

  • Simple detection method with easy "readout" (as compared to the traditional assay)

  • Kits include all five types strains cited in OECD 471 (CoA supplied), quality controlled according to the same guideline 

  • Much less  test compound required.  (10 mg per strain if tested in triplicates, +/- S9, 6 semi-logarithmic compound dilutions)

  • Ames MPF is the preferred system for genotoxic impurities due to its low consumption of compound

  • Significantly less consumption of S9

  • Less environmental pollution due to significantly less "contaminated" waste

  • Less user intervention

  • Download presentation 

Rapid MicroNucleus MoA

Fast Detection of True Positive Compounds. 1 hour analysis time with improved precision
Fastest FISH assay EVER!

Xenometrix AG

Rapid MicroNucleus MoA

Fast Detection of True Positive Compounds. 1 hour analysis time with improved precision
Fastest FISH assay EVER!

Xenometrix AG

Rapid MicroNucleus MoA –
Fast Detection of True Positive Compounds

Fastest FISH assay ever! - Fast, clear identification of Aneugens and Clastogens

 

Introducing the new  In Vitro Human cell micronucleus test ( MNvit), that gives you results in 1 hour.  MNvit  is one of the most widely used in vitro genotoxcity assays combined with, or following the AMES test.

This is a method that provides a comprehensive basis for investigating chromosome damaging potential of a chemical or a radiation.  The Patent pending  MicroNucleus MoA kit provides additional information on the mechanisms of chromosome damage and micronucleus formation: aneugens and clastogens. 

It is also able to provide information on Chromosomal aberrationsand Identify agents that cause structural aberrations in cultured mammalian cells. The kit uses a very simple protocol with minimal additional requirements  and equipment already present in many laboratory environments.

Key features

* 1 hour FISH Assay – fast, reliable genotoxicity assessment
* High specificity – no false positive results due to RNA low-density micronuclei, precipitates, cytoplasmic alteration
* Ready to Use kit including pan-centromeric probes, DAPI and reagents
* Simultaneous DAPI Counterstain
* Fast, clear identification of Aneugens and Clastogens
* FISH staining of centromeres is recommended in OECD TG487
* Chemicals, Pharmaceuticals, Cosmetics, environmental samples
* For all human cells

 

 

 

 


If you cannot find the answer to your problem below then please contact us or telephone 01954 210 200