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Oligo Synthesis

Oligo Synthesis : RNA synthesis

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Ac-A-RNA-CPG

Ac-A-RNA-CPG

Glen Research

Catalogue No.DescriptionPack SizePriceQty
20-3304-01Ac-A-RNA-CPG 0.1g £36.00 Quantity Add to Order
20-3304-02Ac-A-RNA-CPG 0.25g £86.00 Quantity Add to Order
20-3304-10Ac-A-RNA-CPG 1.0g £323.00 Quantity Add to Order
20-3404-13Ac-A-RNA-CPG 1x10µm £205.00 Quantity Add to Order
20-3404-14Ac-A-RNA-CPG 1x15µm £273.00 Quantity Add to Order
20-3404-41Ac-A-RNA-CPG 4x1.0µm £91.00 Quantity Add to Order
20-3404-41MAc-A-RNA-CPG 4x1.0µm £91.00 Quantity Add to Order
20-3404-42Ac-A-RNA-CPG 4x0.2µm £68.00 Quantity Add to Order
20-3404-42MAc-A-RNA-CPG 4x0.2µm £68.00 Quantity Add to Order

Description

Ac-A-RNA-CPG

Structure

Catalog Number: 20-3304-xx

(20-3404-xx)

Description: Ac-A-RNA-CPG

5'-Dimethoxytrityl-N-acetyl-Adenosine,2'-O-acetyl-3'-succinoyl-
long chain alkylamino-CPG


F.W.: 329.21

Diluent: Not Applicable
Coupling: Please refer to the technical bulletin for the synthesis and deprotection procedures. This support should be used in a manner identical to normal protected nucleoside support since it contains the DMT group.
Deprotection: Deprotect using the protocol required by the nucleobases. Technical Bulletin
Storage: Controlled room temperature or lower, dry
Stability in Solution: Not Applicable

TOM-Protected RNA Phosphoramidites

RNA synthesis using monomers containing the 2’-O-TriisopropylsilylOxyMethyl (TOM) group (TOM-Protecting-Group™) is characterized by very high coupling efficiency along with fast, simple deprotection. High coupling efficiency is achieved because the TOM-Protecting-Group exhibits lower steric hindrance than the 2’-O-t-butyldimethylsilyl (TBDMS) group used in our alternative RNA monomers. Fast and reliable deprotection is achieved using methylamine in ethanol/water at room temperature. A further feature of the TOM-Protecting-Group is that during basic steps it can not undergo 2’ to 3’ migration. This migration under basic conditions leads to non-biologically active 2’-5’ linkages when using the TBDMS group. These features allow the TOM-Protected monomers to produce longer oligonucleotides. TOM-Protected RNA monomers are also fully compatible with minor bases with 2’-O-TBDMS protection.

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Protocols

MSDS

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If you cannot find the answer to your problem then please contact us or telephone +44 (0)1954 210 200