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Oligo Synthesis

Oligo Synthesis : CEPs

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G-2'-MOE-Phosphoramidite

G-2'-MOE-Phosphoramidite

Glen Research

Catalogue No.DescriptionPack SizePriceQty
10-3220-05G-2'-MOE-Phosphoramidite 0.5g £34.00 Quantity Add to Order
10-3220-10G-2'-MOE-Phosphoramidite 1.0g £68.00 Quantity Add to Order
10-3220-20G-2'-MOE-Phosphoramidite 2.0g £136.00 Quantity Add to Order
10-3220-SPG-2'-MOE-Phosphoramidite special packaging POA Quantity Add to Order

Description

G-2'-MOE-Phosphoramidite

5'-O-(4,4'-Dimethoxytrityl)-2'-O-methoxyethyl-N2-isobutyryl- guanosine-3'-O-[(2-cyanoethyl)-(N,N-diisopropyl)]-phosphoramidite

G-2'-MOE-Phosphoramidite

Product Specifications

Formula:
C47H60N7O10P
M.W.:
914.01
F.W.:
403.29

Description

Like the very similar 2’-OMe backbone, the 2’-O-methoxyethyl-RNA (2’-MOE) backbone provides enhanced duplex stability, significant nuclease resistance and relatively low toxicity. As a result, 2’-MOE has been an attractive backbone for many therapeutic candidates, several of which have been approved by the FDA. These drugs have included 1) 2’-MOE/DNA chimeras to facilitate RNase H cleavage of target RNA sequences as well as 2) steric blocking oligonucleotides to alter the splicing of mRNA. The standard 2’-MOE nucleotides are A, 5-Me-C, G and 5-Me-U

 

Details

Usage

  • Coupling: 6 minute coupling time recommended
  • Deprotection: No changes needed from standard method recommended by synthesizer manufacturer.
Specifications
Diluent Anhydrous Acetonitrile
Storage Refrigerated storage, maximum of 2-8°C, dry
Stability1-2 Days

Technical Documents

Safety Data Sheet

Glen Report 32.14: New Product — 2'-MOE RNA Phosphoramidites

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