The Ames II assay comprises the frameshift strain TA98, and TAMix, consisting of 6 histidine auxotrophic Salmonella tester strains, TA7001-TA7006. Each of these mutants can be reverted only by a specific transition or transversion, so that all possible base-pair changes can be detected by TAMix.
TA98 and TAMix may be used for mutagenicity screening because they indicate both frameshift and base-pair mutations.
The TA700x tester strains are not included among the recommended tester strains in the current, formal test guidelines. The Xenometrix Ames MPF 98/100 detects a similar mutational spectrum but contains the traditional Ames tester strains TA98 and TA100.
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