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Aptamers

Aptamers: Catalogue Aptamers

Important information

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DEHP Aptamer

DEHP Aptamer

Base Pair Bio

Catalogue No.DescriptionPack SizePriceQty
  • Change to:
  • £
ATW0101-100DEHP Aptamer10 AEU (100ug) POA Quantity Add to Order
ATW0101-25DEHP Aptamer2.5 AEU (25ug) POA Quantity Add to Order

Description

DEHP, or Di(2-ethylhexyl) phthalate (DEHP) is a chemical added to plastics, including PVC/vinyl to increase flexibility. It can be found in many household products, including wallpaper, shower curtains, swimming pool liners, plastic lunch boxes, and some plastic food packaging. It is also found in certain medical devices, including dialysis tubing, surgical gloves and blood storage bags. It is currently regulated in children’s toys and clothing.

Exposure to high doses and extended exposure have caused liver/kidney damage and liver tumors and affected reproductive development in animal studies. The EPA has designated DEHP a probable carcinogen. Exposure to newborns or pregnant women is of particular concern. DEHP can gradually be released from products and accumulate in the home and environment. The greatest risks are ingestion through contaminated food or water and extended exposure through medical devices.

Target:   DEHP

Target Type:   compound

Affinity Constant (Kd):   16.6 nM

Default 3' Linker (Spacer) is 10T. Please submit a custom quote request for other options.

 

 

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References

CDC, ATSDR, Toxic Substances Portal - Di(2-ethylhexyl)phthalate (DEHP), https://www.atsdr.cdc.gov/toxfaqs/tf.asp?id=377&ti.... Accessed Feb 7, 2019. OEHHA. https://www.p65warnings.ca.gov/fact-sheets/di2-eth.... Accessed Feb 7, 2019. EPA. https://cfpub.epa.gov/ncea/iris2/chemicalLanding.c.... Accessed Feb 7, 2019.

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Notes

Please note that aptamers have much lower molecular weights than antibodies. Thus, there are typically five to fifteen times as many moles or molecules of aptamers present in a solution containing an equal mass. For example, 100 micrograms of an aptamer is equivalent to 0.5 to 1.5 mg of antibody, depending on the particular aptamer.

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