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PDA Amino Modifiers Improved stability, handling, and deprotection compatibility
Thursday, 8 October 2020
Phosphoramidites
are very stable products and generally require no special protection
even for summer shipping. One significant exception is amino modifiers
with trifluoroacetyl (TFA) protecting groups. These products are
inexpensive, easy to use, and industry
standards. However, as a viscous oil, they are not very stable and
subject to degradation, particularly during shipping.
Phthalic diamide (PDA) amino modifiers are analogous to their TFA
counterparts—with one significant contrasting property—they are granular
powders. This important property allows for straightforward handling,
storage, and aliquoting and leads to a significant
increase in stability. Unique to Glen Research, PDA amino-modifiers are
fully stable even for extended summer shipping.
Article Source:
Glen Research