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Oligo Synthesis

Oligo Synthesis : CEPs

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Methacrylate C6 Phosphoramidite

Methacrylate C6 Phosphoramidite is a terminus modifier that attaches a methacrylate functional group to an oligonucleotide.

Glen Research

Description

Methacrylate C6 Phosphoramidite is a terminus modifier that attaches a methacrylate functional group to an oligonucleotide.  Methacrylate-modified oligonucleotides can be reacted with thiol-modified surfaces or incorporated into polyacrylamide gels. Methacrylate-modified oligonucleotides have been used to generate oligonucleotide labeled hydrogels, microspheres, microarrays, and functionalized polymeric surfaces, among other applications. These oligonucleotide-labeled surfaces and polymers have been used for purification, hybridization detection, PCR amplification, affinity capture, aptamers, sequencing, and biosensors.  Recent applications of methacrylate-labeled oligonucleotides include aptamer-based hydrogels, molecular imprinting, and Expansion Microscopy.

Usage

  • Coupling: No changes needed from standard method recommended by synthesizer manufacturer.
  • Deprotection: No changes needed from standard method recommended by synthesizer manufacturer.

 

 

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Protocols

Safety Data Sheet (on Glen's website)

Glen Report 31.14: New Product - Methacrylate C6 Phosphoramidite

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References

1. F.N. Rehman, et al., Nucl Acid Res, 1999, 27, 649-655.

2. J. Liu, et al., Anal Bioanal Chem, 2012, 402, 187-94.

3. Z. Zhang and J. Liu, Small, (In Press), 201805246.

4. N. Tsanov, et al., Nucleic Acids Res, 2016, 44, e165.

5. R. Liu, et al., ACS Applied Materials & Interfaces, 2015, 7, 6982-6990.

6. F. Chen, P.W. Tillberg, and E.S. Boyden, Science (New York, N.Y.), 2015, 347, 543-548.

7. E.S. Boyden, 2016, http://bit.ly/2LgJz3d

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Notes

Product Specifications

Formula:C19H36N3O3P

M.W.: 385.48

F.W.: 248.24

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Applications & Benefits

Usage

Coupling: No changes needed from standard method recommended by synthesizer manufacturer. Deprotection: No changes needed from standard method recommended by synthesizer manufacturer.

If you cannot find the answer to your problem then please contact us or telephone +44 (0)1954 210 200