Cambio - Excellence in Molecular Biology

Oligo Synthesis

Oligo Synthesis : CEPs

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2’-OMe-Thiophosphoramidites

2’-OMe-Thiophosphoramidites

Glen Research

Catalogue No.DescriptionPack SizePriceQty
10-3170-022'-OMe-A-Thiophosphoramidite0.25g £576.00£529.92Offer until : 29-Feb-2020Offer Code : GLEN88% off all Glen Research products View Offer Quantity Add to Order
10-3170-902'-OMe-A-Thiophosphoramidite100umole £240.00£220.80Offer until : 29-Feb-2020Offer Code : GLEN88% off all Glen Research products View Offer Quantity Add to Order
10-3171-022’-OMe-C-Thiophosphoramidite0.25g £576.00£529.92Offer until : 29-Feb-2020Offer Code : GLEN88% off all Glen Research products View Offer Quantity Add to Order
10-3171-902’-OMe-C-Thiophosphoramidite100umole £240.00£220.80Offer until : 29-Feb-2020Offer Code : GLEN88% off all Glen Research products View Offer Quantity Add to Order
10-3172-022’-OMe-G-Thiophosphoramidite0.25g £576.00£529.92Offer until : 29-Feb-2020Offer Code : GLEN88% off all Glen Research products View Offer Quantity Add to Order
10-3172-902’-OMe-G-Thiophosphoramidite100umole £240.00£220.80Offer until : 29-Feb-2020Offer Code : GLEN88% off all Glen Research products View Offer Quantity Add to Order
10-3173-022’-OMe-U-Thiophosphoramidite0.25g £576.00£529.92Offer until : 29-Feb-2020Offer Code : GLEN88% off all Glen Research products View Offer Quantity Add to Order
10-3173-902’-OMe-U-Thiophosphoramidite100umole £240.00£220.80Offer until : 29-Feb-2020Offer Code : GLEN88% off all Glen Research products View Offer Quantity Add to Order

2’-OMe-Thiophosphoramidites

2’-OMe-Thiophosphoramidites

Glen Research

2’-OMe-Thiophosphoramidites

The phosphorodithioate linkage (PS2) is both achiral and essentially resistant to nucleases. Previous studies have shown very interesting results which include observations that DNA with PS2 linkages activates RNase H , strongly inhibits human immunodeficiency virus (HIV) reverse transcriptase, induces β-cell proliferation and differentiation, and is completely resistant to hydrolysis by various nucleases. 2'-OMe- RNA Thiophosphoramidites are RNA monomers designed to produce oligos combining the PS2 linkage with the 2'-O-methyl ribose modification. These PS2-modified RNA oligos have potential for use in siRNAs and dithiophosphate aptamers (thioaptamers).

2'-OMe-A-Thiophosphoramidite   2’-OMe-C-Thiophosphoramidite

2’-OMe-G-Thiophosphoramidite   2’-OMe-U-Thiophosphoramidite

If you cannot find the answer to your problem below then please contact us or telephone 01954 210 200

2’-OMe-Thiophosphoramidites

2’-OMe-Thiophosphoramidites

Glen Research

Glen Report 27.2: introducing 2'-OMe-Thiophosphoramidites

If you cannot find the answer to your problem below then please contact us or telephone 01954 210 200

2’-OMe-Thiophosphoramidites

2’-OMe-Thiophosphoramidites

Glen Research

Formula: C52H53N6O8PS2 
M.W.: 985.12 
F.W.: 375.36 

Diluent: 10% DCM in Acetonitrile

Coupling: See Technical Bulletin

Deprotection: See Technical Bulletin for details (http://www.glenresearch.com/Technical/TB_Thioamidites2015.pdf).

Storage: Storage: Freezer storage, -10 to -30°C, dry

Stability in Solution: Use Immediately

If you cannot find the answer to your problem below then please contact us or telephone 01954 210 200