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Aptamers

Aptamers: Catalogue Aptamers

Important information

Do you know what modifications you will need for your aptamers?  see "modifications" section for details

Human Granzyme B

Human Granzyme B aptamer

Base Pair Bio

Catalogue No.DescriptionPack SizePriceQty
ATW0047-100Human Granzyme B 10 AEU (100ug) POA Quantity Add to Order
ATW0047-25Human Granzyme B 2.5 AEU (25ug) POA Quantity Add to Order

Description

Granzyme B is a serine protease that induces apoptosis. It is involved with processing of cytokines and degradation of extracellular matrix proteins in chronic inflammation and wound healing. The preprotein is secreted by natural killer cells and cytotoxic T lymphocytes, then proteolytically processed to form the active protease.

Target:   Granzyme B

Target Species:   human

Target Type:   protein

Affinity Constant (Kd):   9 nM

Default 3' Linker (Spacer) is 10T. Please submit a custom quote request for other options.

Aptamer was selected at Base Pair from a randomized DNA library against the target protein. Proprietary methods were then used to select the aptamer.

Aptamer folding instruction

Datasheet

0.1uM synthesis scale (20-200ug)
Please choose your modification and add as an extra catalogue number:
ATWUNMOD - Unmodified
ATWAMINE - Amine modification
ATWBIOTIN - Biotin modification
ATWTHIOL - Thiol modification (extra charge)
ATWFLUOR - Fluor (all) modification (extra charge)

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Protocols

Datasheet

 

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References

www.genecards.org/cgi-bin/carddisp.pl?gene=GZMB

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Notes

Please note that aptamers have much lower molecular weights than antibodies. Thus, there are typically five to fifteen times as many moles or molecules of aptamers present in a solution containing an equal mass. For example, 100 micrograms of an aptamer is equivalent to 0.5 to 1.5 mg of antibody, depending on the particular aptamer.

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Related products

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