TGF-beta is secreted by many cell types, including macrophages, in a
latent form in which it is complexed with two other polypeptides, latent
TGF-beta binding protein (LTBP) and latency associated peptide (LAP).
Serum proteinases such as plasmin catalyze the release of active
TGF-beta from the complex. This often occurs on the surface of
macrophages where the latent TGF-beta complex is bound to CD36 via its
ligand, thrombospondin-1 (TSP-1). This aptamer was selected by
scientists at Base Pair Biotechnologies using proprietary methods and
recombinant Latency Associated Peptide (LAP), [R&D Systems, Cat#
246-LP/CF] as a target.
Target: LAP / TGF beta 1 Complex (Latency Associated Peptide, Transforming Growth Factor Beta 1)
Target Species: human
Target Type: protein
Affinity Constant (Kd): 5.6 nM
Default 3' Linker (Spacer) is 10T. Please submit a custom quote request for other options.
Please choose your modification and add as an extra catalogue number:
ATWUNMOD - Unmodified
ATWAMINE - Amine modification
ATWBIOTIN - Biotin modification
ATWTHIOL - Thiol modification (extra charge)
ATWFLUOR - Fluor (all) modification (extra charge)
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