Interleukin 6 (IL6) is an interleukin that acts as both a pro-inflammatory and anti-inflammatory cytokine. It is secreted by T cells and macrophages to stimulate immune response and is also considered a "myokine," a cytokine produced from muscle, and is elevated in response to muscle contraction. It is significantly elevated with exercise, and precedes the appearance of other cytokines in the circulation. During exercise, it is thought to act in a hormone-like manner to mobilize extracellular substrates and/or augment substrate delivery. Additionally, osteoblasts secrete IL6 to stimulate osteoclast formation. Smooth muscle cells in the tunica media of many blood vessels also produce IL6 as a pro-inflammatory cytokine. IL6's role as an anti-inflammatory cytokine is mediated through its inhibitory effects on TNF-alpha and IL1, and activation of IL1ra and IL10.
Target: IL-6 (Interleukin-6)
Target Species: murine
Target Type: protein
Affinity Constant (Kd): 5.4 nM
Default 3' Linker (Spacer) is 10T. Please submit a custom quote request for other options.
This aptamer was selected by scientists at Base Pair Biotechnologies using proprietary methods, recombinant Murine Interleukin 6, [BioLegend Cat# 575706] and 1X PBS, pH = 7.4. ATW0077 is a sandwich pair with ATW0082 and ATW0083. Let us know if you have any questions about its development or potential uses.
Aptamer information Kd 7.4 ± 1.7 nM
IL6 ATW0077.ATW0082 #EALRN#D92GX datasheet
IL6 ATW0077.ATW0083 #EALRN#D95W1 datasheet
Please choose your modification and add as an extra catalogue number:
ATWUNMOD - Unmodified
ATWAMINE - Amine modification
ATWBIOTIN - Biotin modification
ATWTHIOL - Thiol modification (extra charge)
ATWFLUOR - Fluor (all) modification (extra charge)
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