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While iodine oxidation in oligonucleotide synthesis is standard, non-aqueous oxidation can be very effective in situations where components of the synthesis are sensitive to moisture and/or iodine. For many years, we have been recommending (1S)-( )-(10-camphorsulfonyl)-oxaziridine (CSO) as the best non-aqueous alternative to iodine oxidation. We are now offering 0.5M CSO in acetonitrile as a reasonably cost-effective alternative oxidizer. And we already offer 0.1M CSO for use in PACE chemistry. More ...
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Catalog Number: 40-4632-xx
Description: 0.5M CSO in Anhydrous Acetonitrile
| (1S)-( )-(10-Camphorsulfonyl)-oxaziridine (CSO) |
| Formula: C10H15NO3S (CSO) |
M.W.: 229.3 (CSO) |
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Diluent: Anhydrous Acetonitrile |
| Synthesis: A non-aqueous oxidizer. Replaces Oxidizing Solution on synthesizer. |
| Oxidation: For phosphodiester synthesis, a minimum oxidation time of 3 minutes is recommended. |
| Storage: Controlled room temperature |
| Stability in Solution: 12 Months |
ALTERNATIVE SOLVENTS/REAGENTS
Glen Research offers alternative solvents and reagents in suitable bottles and formulations for use on various DNA synthesizers. All solvents and reagents are prepared to our exacting specifications to ensure the highest coupling efficiencies and are passed through a 0.2 micron filter during packaging to eliminate particulate contamination. Glen Research offers the activators below in powder form for later dissolution in anhydrous acetonitrile or as a prepared solution.
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