Cambio - Excellence in Molecular Biology

Oligo Synthesis

Oligo Synthesis : Reagents

Prices quoted are for single packs only. For multiples of the same product please request a quote. Some of Glen's products are hazardous and may be subject to additional shipping charges. Full product information is available on Glen Research's website.

0.5M CSO in Anhydrous Acetonitrile

0.5M CSO in Anhydrous Acetonitrile for ABI or Expedite

Glen Research

Catalogue No.DescriptionPack SizePriceQty
40-4632-520.5M CSO in Anhydrous Acetonitrile (ABI)200ml £200.00 Quantity Add to Order
40-4632-52E0.5M CSO in Anhydrous Acetonitrile (Expedite)200ml £200.00 Quantity Add to Order

0.5M CSO in Anhydrous Acetonitrile

0.5M CSO in Anhydrous Acetonitrile for ABI or Expedite

Glen Research

NON-AQUEOUS OXIDATION USING 0.5M CSO

While iodine oxidation in oligonucleotide synthesis is standard, non-aqueous oxidation can be very effective in situations where components of the synthesis are sensitive to moisture and/or iodine. For many years, we have been recommending (1S)-( )-(10-camphorsulfonyl)-oxaziridine (CSO) as the best non-aqueous alternative to iodine oxidation. We are now offering 0.5M CSO in acetonitrile as a reasonably cost-effective alternative oxidizer. And we already offer 0.1M CSO for use in PACE chemistry.  More ...

CSO

Structure

Catalog Number: 40-4632-xx

Description: 0.5M CSO in Anhydrous Acetonitrile

(1S)-( )-(10-Camphorsulfonyl)-oxaziridine (CSO)
Formula: C10H15NO3S (CSO) M.W.: 229.3 (CSO)

Diluent: Anhydrous Acetonitrile
Synthesis: A non-aqueous oxidizer. Replaces Oxidizing Solution on synthesizer.
Oxidation: For phosphodiester synthesis, a minimum oxidation time of 3 minutes is recommended.
Storage: Controlled room temperature
Stability in Solution: 12 Months

ALTERNATIVE SOLVENTS/REAGENTS

Glen Research offers alternative solvents and reagents in suitable bottles and formulations for use on various DNA synthesizers. All solvents and reagents are prepared to our exacting specifications to ensure the highest coupling efficiencies and are passed through a 0.2 micron filter during packaging to eliminate particulate contamination. Glen Research offers the activators below in powder form for later dissolution in anhydrous acetonitrile or as a prepared solution.

If you cannot find the answer to your problem below then please contact us or telephone 01954 210 200

0.5M CSO in Anhydrous Acetonitrile

0.5M CSO in Anhydrous Acetonitrile for ABI or Expedite

Glen Research

MSDS

Glen Report 9.1

Glen Report 22.2

If you cannot find the answer to your problem below then please contact us or telephone 01954 210 200

0.5M CSO in Anhydrous Acetonitrile

0.5M CSO in Anhydrous Acetonitrile for ABI or Expedite

Glen Research

  1. M H Caruthers, et al., Gene Amplif Anal 1983, 3, 1-26
  2. M A Reynolds, et al., Nucleic Acids Res, 1996, 24, 4584-4591
  3. The Glen Report, 1996, 9, 8-9
  4. I Ugi, et al., Nucleosides and Nucleotides, 1988, 7, 605-608
  5. S L Beaucage and M H Caruthers, Current Protocols in Nucleic Acid Chemistry, 2000, 1, 3.3.1-3.3.20
  6. Y Hayakawa, M Uchiyama, and R Noyori, Tetrahedron Letters, 1996, 27, 4191-4194
  7. N D Sinha, D P Michaud, S K Ray, and R A Casale, Nucleic Acids Res, 1994, 22, 3119-3123
  8. D J Dellinger, D M Sheehan, N K Christensen, J G Lindberg, and M H Caruthers, J Amer Chem Soc, 2003, 125, 940-950
  9. T P Prakash, J F Johnston, M J Graham, T P Condon, and M Manoharan, Nucleic Acids Res, 2004, 32, 828-33

If you cannot find the answer to your problem below then please contact us or telephone 01954 210 200