Methicillin-resistant Staphylococcus aureus, abbreviated MRSA, is one of a number of greatly feared strains of S. aureus which have become resistant to most B lactam antibiotics. Resistance is conferred by the mecA gene, which codes for an altered penicillin-binding protein (PBP2a or PBP2') that has a lower affinity for binding B lactams (penicillins,cephalosporins, and carbapenems). This allows for resistance to all B lactam antibiotics, and obviates their clinical use during MRSA infections.
This aptamer was selected by scientists at Base Pair Biotechnologies using proprietary methods and Recombinant Staphylococcus aureus PBP2a, [Ray Biotech Cat # 230-00051] as a target and 1X PBS, pH 7.4, 0.01% BSA, 0.002% Tween20. Let us know if you have any questions about its development or potential uses.
Target: PBP-2a, Penicillin-binding-protein 2a from Staphylococcus aureus
Target Species: bacterial
Target Type: protein
Affinity Constant (Kd): 23.5 nM
Aptamer information Kd 23.5 nM
MRSA ATW0033 #820 datasheet
Please choose your modification and add as an extra catalogue number:
ATWUNMOD - Unmodified
ATWAMINE - Amine modification
ATWBIOTIN - Biotin modification
ATWTHIOL - Thiol modification (extra charge)
ATWFLUOR - Fluor (all) modification (extra charge)
If you cannot find the answer to your problem then please contact us or telephone +44 (0)1954 210 200